Alpha-Lipoic Acid: Antioxidant Support for Your Roll

ALA is a unique antioxidant that works in both fat and water environments—perfect for protecting brain cells during MDMA-induced oxidative stress.

Why ALA Helps
Alpha-Lipoic Acid is a “universal antioxidant,” meaning it works in both water- and fat-soluble environments. That makes it especially powerful for protecting neurons, which are rich in fatty membranes

The Research:
Studies show ALA can regenerate other antioxidants (like Vitamin C and Vitamin E) while improving mitochondrial function. This combo makes it particularly interesting in the context of MDMA-induced oxidative stress.

Supporting Evidence
ALA has been shown to fully prevent serotonergic deficits and neurotoxic changes in MDMA-exposed rats PubMedPubMed Central.

Takeaway
ALA acts as a powerful antioxidant captain—reinforcing your defense team when it matters most.

👉 We include ALA in the AfterGlow Pack for its proven neuroprotective impact.

Orrrrrrrr for those who are a little like me and like the pharmacology behind it, ill dive a little deeper so there you. To say the least; It is a powerful antioxidant. It scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements are racemic, or a mix of both. Racemic ALA does not reach as high of plasma levels as R-ALA, nor does it stay in the blood as long. It’s half life is very short, ~30min. If that is all you can find, it’s much better than nothing. R-ALA by itself is very unstable, and is not suitable for supplementation. This is where bonding it to sodium comes into play. Na-R-ALA, or sodium R alpha lipoic acid, allows for stable delivery of just the dextrorotory isomer of ALA. Here is a study on the benefits of Na-R-ALA. And here is the study showing that ALA prevented MDMA induced neurotoxicity, even though body temperatures still rose.

 

So this is why we include only the best version, Na-R-ALA, in our packs